Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9NS28
UPID:
RGS18_HUMAN
Alternative names:
-
Alternative UPACC:
Q9NS28; B2RD23
Background:
Regulator of G-protein signaling 18 (RGS18) is a pivotal protein that modulates G-protein signaling pathways. It inhibits signal transduction by enhancing the GTPase activity of G protein alpha subunits, leading them into their inactive GDP-bound form. RGS18 specifically interacts with G(i) alpha-1, G(i) alpha-2, G(i) alpha-3, and G(q) alpha, showcasing its critical role in cellular signaling.
Therapeutic significance:
Understanding the role of Regulator of G-protein signaling 18 could open doors to potential therapeutic strategies. Its involvement in key signaling pathways suggests its potential as a target in designing drugs to modulate G-protein-mediated signals, offering new avenues for therapeutic intervention.