Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9NS69
UPID:
TOM22_HUMAN
Alternative names:
1C9-2; Translocase of outer membrane 22 kDa subunit homolog
Alternative UPACC:
Q9NS69
Background:
The Mitochondrial import receptor subunit TOM22 homolog, also known as 1C9-2 and Translocase of outer membrane 22 kDa subunit homolog, plays a pivotal role in cellular energy production. It serves as a central receptor component of the translocase of the outer membrane of mitochondria (TOM complex), essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. By facilitating the movement of preproteins into the translocation pore, in conjunction with TOM20, it ensures the proper functioning of mitochondrial processes.
Therapeutic significance:
Understanding the role of Mitochondrial import receptor subunit TOM22 homolog could open doors to potential therapeutic strategies.