Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9NS84
UPID:
CHST7_HUMAN
Alternative names:
Chondroitin 6-sulfotransferase 2; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5; N-acetylglucosamine 6-O-sulfotransferase 4
Alternative UPACC:
Q9NS84; O75667
Background:
Carbohydrate sulfotransferase 7, also known as Chondroitin 6-sulfotransferase 2, plays a crucial role in the sulfation process, utilizing 3'-phospho-5'-adenylyl sulfate as a donor. It preferentially targets mannose-linked N-acetylglucosamine residues and is involved in the modification of chondroitin and mucin-type oligosaccharides, impacting various biological processes.
Therapeutic significance:
Understanding the role of Carbohydrate sulfotransferase 7 could open doors to potential therapeutic strategies, offering insights into novel treatment avenues for diseases where sulfation patterns play a critical role.