Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9NS86
UPID:
LANC2_HUMAN
Alternative names:
Testis-specific adriamycin sensitivity protein
Alternative UPACC:
Q9NS86; B2R8D4; Q6NSL4; Q8TCQ3; Q9BSR1
Background:
LanC-like protein 2, also known as the Testis-specific adriamycin sensitivity protein, plays a crucial role in cellular processes by being necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. This protein's unique function highlights its importance in the regulation of cellular responses to environmental stimuli.
Therapeutic significance:
Understanding the role of LanC-like protein 2 could open doors to potential therapeutic strategies. Its involvement in the ABA signaling pathway suggests a pivotal role in cellular processes that could be leveraged in drug discovery and development.