Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9NSB8
UPID:
HOME2_HUMAN
Alternative names:
Cupidin
Alternative UPACC:
Q9NSB8; O95269; O95349; Q9NSB6; Q9NSB7; Q9UNT7
Background:
Homer protein homolog 2, also known as Cupidin, plays a crucial role in synaptic transmission and plasticity. It functions as a postsynaptic density scaffolding protein, facilitating the interaction between various receptors and ion channels, including GRM1, GRM5, and ITPR1. This interaction is essential for the coupling of surface receptors to intracellular calcium release, pivotal for synaptic function.
Therapeutic significance:
Given its critical role in maintaining synaptic plasticity and its requirement for normal hearing, as evidenced by its involvement in Deafness, autosomal dominant, 68, Homer protein homolog 2 presents a promising target for therapeutic intervention in sensorineural hearing loss.