Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9NSE4
UPID:
SYIM_HUMAN
Alternative names:
Isoleucyl-tRNA synthetase
Alternative UPACC:
Q9NSE4; B2RPG8; Q1M2P9; Q6PI85; Q7L439; Q86WU9; Q96D91; Q9H9Q8; Q9NW42
Background:
Isoleucine--tRNA ligase, mitochondrial, also known as Isoleucyl-tRNA synthetase, plays a crucial role in protein synthesis by catalyzing the attachment of isoleucine to tRNA. This process is vital for the accurate translation of the genetic code into functional proteins.
Therapeutic significance:
The protein is implicated in a complex disorder involving cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia. Understanding the role of Isoleucine--tRNA ligase, mitochondrial could open doors to potential therapeutic strategies for this multifaceted disease.