Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9NSY2
UPID:
STAR5_HUMAN
Alternative names:
START domain-containing protein 5
Alternative UPACC:
Q9NSY2; P59094
Background:
StAR-related lipid transfer protein 5, also known as START domain-containing protein 5, plays a crucial role in the intracellular transport of sterols and other lipids. Its ability to potentially bind cholesterol or other sterols suggests a significant function in cellular lipid metabolism and homeostasis.
Therapeutic significance:
Understanding the role of StAR-related lipid transfer protein 5 could open doors to potential therapeutic strategies. Its involvement in lipid transport and metabolism positions it as a key target for addressing disorders related to lipid imbalances.