Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9NV88
UPID:
INT9_HUMAN
Alternative names:
Protein related to CPSF subunits of 74 kDa
Alternative UPACC:
Q9NV88; B7Z560; B7Z6M5; O00224; Q8TB16
Background:
Integrator complex subunit 9, alternatively known as Protein related to CPSF subunits of 74 kDa, plays a crucial role in the transcription and processing of small nuclear RNAs (snRNA) U1 and U2. It is a part of the Integrator (INT) complex, which associates with the C-terminal domain (CTD) of RNA polymerase II's largest subunit (POLR2A), facilitating the recruitment of cytoplasmic dynein to the nuclear envelope.
Therapeutic significance:
Understanding the role of Integrator complex subunit 9 could open doors to potential therapeutic strategies.