Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9NVH2
UPID:
INT7_HUMAN
Alternative names:
-
Alternative UPACC:
Q9NVH2; B4DLZ6; B7WNP6; B7WPB6; Q8N4K7; Q8WUH5; Q9H9V3; Q9NVU5; Q9UFC6; Q9UFM3
Background:
Integrator complex subunit 7 plays a pivotal role in the transcription and processing of small nuclear RNAs (snRNAs) U1 and U2, essential components of the spliceosome. It is part of the Integrator complex, which is crucial for snRNA gene expression and is linked to the RNA polymerase II. This protein also contributes to the DNA damage response signaling, highlighting its importance in maintaining genomic integrity.
Therapeutic significance:
Understanding the role of Integrator complex subunit 7 could open doors to potential therapeutic strategies. Its involvement in crucial cellular processes such as snRNA transcription, processing, and DNA damage response, positions it as a key target for drug discovery efforts aimed at treating diseases linked to genetic dysregulation and cellular damage.