Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9NVJ2
UPID:
ARL8B_HUMAN
Alternative names:
ADP-ribosylation factor-like protein 10C; Novel small G protein indispensable for equal chromosome segregation 1
Alternative UPACC:
Q9NVJ2; B4DI85
Background:
ADP-ribosylation factor-like protein 8B (ARL8B) is a small GTPase pivotal in lysosomal positioning and function. It transitions between active GTP-bound and inactive GDP-bound states, engaging with effector proteins to regulate lysosomal transport, fusion, and positioning. ARL8B's specific localization to lysosomal membranes facilitates anterograde lysosomal motility, essential for nutrient sensing, NK cell-mediated cytotoxicity, and antigen presentation. It plays a crucial role in endosome to lysosome trafficking, impacting antigen presentation, microbial killing, and plasma membrane repair during infections.
Therapeutic significance:
Understanding the role of ADP-ribosylation factor-like protein 8B could open doors to potential therapeutic strategies.