Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9NVU0
UPID:
RPC5_HUMAN
Alternative names:
DNA-directed RNA polymerase III 80 kDa polypeptide
Alternative UPACC:
Q9NVU0; B4DL24; B4DUP6; H3BT11; Q9BWF7; Q9H8W8; Q9H907; Q9P276
Background:
DNA-directed RNA polymerase III subunit RPC5, also known as the 80 kDa polypeptide, plays a pivotal role in the transcription of DNA into RNA, utilizing ribonucleoside triphosphates. It is a specific component of RNA polymerase III, essential for synthesizing small RNAs like 5S rRNA and tRNAs. This protein is crucial for transcription from RNA polymerase III promoters and is involved in the innate immune response by sensing intracellular bacteria and DNA viruses.
Therapeutic significance:
Understanding the role of DNA-directed RNA polymerase III subunit RPC5 could open doors to potential therapeutic strategies.