Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9NWS8
UPID:
RMND1_HUMAN
Alternative names:
-
Alternative UPACC:
Q9NWS8; A8K8H4; Q0VDG6; Q5SZ48; Q5SZ83; Q6NSC5; Q96EN7
Background:
The Required for meiotic nuclear division protein 1 homolog (Q9NWS8) plays a crucial role in mitochondrial translation. It is instrumental in the assembly or maintenance of the mitochondrial ribosome, facilitating the synthesis of proteins necessary for mitochondrial function.
Therapeutic significance:
Its association with Combined oxidative phosphorylation deficiency 11, a severe disorder affecting multiple systems, underscores its potential as a target for therapeutic intervention. Understanding the role of this protein could open doors to potential therapeutic strategies.