Focused On-demand Library for H/ACA ribonucleoprotein complex subunit 2

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.

Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

Our top-notch dedicated system is used to design specialised libraries.

 Fig. 1. The sreening workflow of Receptor.AI

By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.

Our library stands out due to several important features:

  • The Receptor.AI platform compiles comprehensive data on the target protein, encompassing previous experiments, literature, known ligands, structural details, and more, leading to a higher chance of selecting the most relevant compounds.
  • Advanced molecular simulations on the platform help pinpoint potential binding sites, making the compounds in our focused library ideal for finding allosteric inhibitors and targeting cryptic pockets.
  • Receptor.AI boasts over 50 tailor-made AI models, rigorously tested and proven in various drug discovery projects and research initiatives. They are crafted for efficacy, dependability, and precision, all of which are key in creating our focused libraries.
  • Beyond creating focused libraries, Receptor.AI offers comprehensive services and complete solutions throughout the preclinical drug discovery phase. Our success-based pricing model minimises risk and maximises the mutual benefits of the project's success.







Alternative names:

Nucleolar protein family A member 2; snoRNP protein NHP2

Alternative UPACC:

Q9NX24; A6NKY8; Q9P095


H/ACA ribonucleoprotein complex subunit 2, also known as Nucleolar protein family A member 2 or snoRNP protein NHP2, plays a crucial role in ribosome biogenesis and telomere maintenance. It is a part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, catalyzing the pseudouridylation of rRNA, which stabilizes the conformation of rRNAs. Additionally, it is involved in the processing or intranuclear trafficking of TERC, essential for telomerase reverse transcriptase (TERT) holoenzyme function.

Therapeutic significance:

Dyskeratosis congenita, autosomal recessive, 2, a rare multisystem disorder characterized by defective telomere maintenance, implicates the vital role of H/ACA ribonucleoprotein complex subunit 2 in disease pathology. Understanding its function could lead to novel therapeutic strategies targeting bone marrow failure, pulmonary fibrosis, and other related complications.

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