Focused On-demand Library for Protein O-mannosyl-transferase TMEM260

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.

Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.

The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.

We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.

Fig. 1. The sreening workflow of Receptor.AI

This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.

Key features that set our library apart include:

The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.

partner

Reaxense

upacc

Q9NX78

UPID:

TM260_HUMAN

Alternative names:

Transmembrane protein 260

Alternative UPACC:

Q9NX78; A8KAN4; B3KPF5; Q0VAA1; Q86XE1

Background:

Protein O-mannosyl-transferase TMEM260, also known as Transmembrane protein 260, plays a crucial role in cellular function by transferring mannosyl residues to serine or threonine residues of proteins. This specific glycosylation process, involving the IPT/TIG domain of target proteins such as MET and MST1R/RON, results in the formation of single mannose glycans that are not further elongated or modified.

Therapeutic significance:

Given its involvement in Structural heart defects and renal anomalies syndrome, a deeper understanding of TMEM260's function could pave the way for innovative therapeutic approaches targeting this autosomal recessive syndrome, characterized by a spectrum of central nervous system, cardiac, renal, and digit abnormalities.