Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9NXU5
UPID:
ARL15_HUMAN
Alternative names:
ADP-ribosylation factor-related protein 2
Alternative UPACC:
Q9NXU5; Q6IAD0
Background:
ADP-ribosylation factor-like protein 15, also known as ADP-ribosylation factor-related protein 2, plays a crucial role in cellular processes, including intracellular trafficking and signal transduction. Its unique structure and function position it as a key player in maintaining cellular homeostasis and regulating protein transport.
Therapeutic significance:
Understanding the role of ADP-ribosylation factor-like protein 15 could open doors to potential therapeutic strategies. Its involvement in fundamental cellular processes makes it a promising target for drug discovery, aiming to correct cellular dysfunctions associated with various diseases.