Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9NXW9
UPID:
ALKB4_HUMAN
Alternative names:
Alkylated DNA repair protein alkB homolog 4; DNA N6-methyl adenine demethylase ALKBH4; Lysine-specific demethylase ALKBH4
Alternative UPACC:
Q9NXW9; Q53H92; Q9H6A4
Background:
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4, also known as ALKBH4, plays a crucial role in cellular processes by demethylating monomethylated actin at 'Lys-84' and DNA methylated on adenine. This activity is pivotal for maintaining actomyosin dynamics, which are essential for cell migration and cytokinesis.
Therapeutic significance:
Understanding the role of Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 could open doors to potential therapeutic strategies.