Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9NY12
UPID:
GAR1_HUMAN
Alternative names:
Nucleolar protein family A member 1; snoRNP protein GAR1
Alternative UPACC:
Q9NY12; Q5MJQ2
Background:
H/ACA ribonucleoprotein complex subunit 1, also known as Nucleolar protein family A member 1 or snoRNP protein GAR1, plays a pivotal role in ribosome biogenesis and telomere maintenance. It is a crucial component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, facilitating the pseudouridylation of rRNA, a process essential for the stabilization of rRNA structure.
Therapeutic significance:
Understanding the role of H/ACA ribonucleoprotein complex subunit 1 could open doors to potential therapeutic strategies, particularly in diseases where ribosome biogenesis and telomere maintenance are compromised.