Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9NY64
UPID:
GTR8_HUMAN
Alternative names:
Glucose transporter type 8; Glucose transporter type X1
Alternative UPACC:
Q9NY64; Q8WUZ9; Q9NSC4
Background:
Solute carrier family 2, facilitated glucose transporter member 8, also known as Glucose transporter type 8 and Glucose transporter type X1, plays a crucial role in cellular metabolism. It is an insulin-regulated facilitative hexose transporter, primarily mediating the transport of glucose and fructose across cell membranes. Additionally, it has the capability to transport dehydroascorbate, highlighting its versatility in substrate specificity.
Therapeutic significance:
Understanding the role of Solute carrier family 2, facilitated glucose transporter member 8 could open doors to potential therapeutic strategies. Its pivotal function in glucose and fructose transport underscores its importance in metabolic processes, suggesting that modulation of its activity could offer new avenues for managing metabolic disorders.