Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9NY93
UPID:
DDX56_HUMAN
Alternative names:
ATP-dependent 61 kDa nucleolar RNA helicase; DEAD box protein 21; DEAD box protein 56
Alternative UPACC:
Q9NY93; A4D2K9; C9JV95; Q6IAE2; Q9H9I8
Background:
Probable ATP-dependent RNA helicase DDX56, also known as ATP-dependent 61 kDa nucleolar RNA helicase, DEAD box protein 21, and DEAD box protein 56, is a multifunctional protein involved in various biological processes. These include innate immunity, ribosome biogenesis, and nucleolus organization, highlighting its essential role in maintaining nucleolar integrity in planarian stem cells and embryonic stem cells proliferation. DDX56 also regulates antiviral innate immunity by inhibiting virus-triggered signaling nuclear translocation of IRF3.
Therapeutic significance:
Understanding the role of Probable ATP-dependent RNA helicase DDX56 could open doors to potential therapeutic strategies.