Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9NYJ7
UPID:
DLL3_HUMAN
Alternative names:
Drosophila Delta homolog 3
Alternative UPACC:
Q9NYJ7; E9PFG2; Q8NBS4
Background:
Delta-like protein 3, also known as Drosophila Delta homolog 3, plays a pivotal role in inhibiting primary neurogenesis and is essential for the formation of somite boundaries during the segmentation of the paraxial mesoderm. Its involvement in diverting neurons along specific differentiation pathways underscores its significance in developmental biology.
Therapeutic significance:
Delta-like protein 3's association with Spondylocostal dysostosis 1, an autosomal recessive condition characterized by severe skeletal malformations, highlights its potential as a therapeutic target. Understanding the role of Delta-like protein 3 could open doors to potential therapeutic strategies for treating this debilitating disease.