Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9NZ94
UPID:
NLGN3_HUMAN
Alternative names:
Gliotactin homolog
Alternative UPACC:
Q9NZ94; B2RBK1; D2X2H6; D3DVV0; D3DVV1; Q86V51; Q8NCD0; Q9NZ95; Q9NZ96; Q9NZ97; Q9P248
Background:
Neuroligin-3, also known as Gliotactin homolog, is a cell surface protein pivotal in cell-cell interactions, particularly with neurexin family members. It plays a crucial role in synapse function and synaptic signal transmission, potentially by clustering other synaptic proteins. It is involved in the initial formation of synapses and may facilitate glia-glia or glia-neuron interactions in the developing peripheral nervous system.
Therapeutic significance:
Given its association with Autism, X-linked 1, a developmental disorder marked by social and communication impairments, Neuroligin-3's study could lead to novel therapeutic strategies targeting synaptic dysfunctions in autism spectrum disorders.