Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9NZM3
UPID:
ITSN2_HUMAN
Alternative names:
SH3 domain-containing protein 1B; SH3P18; SH3P18-like WASP-associated protein
Alternative UPACC:
Q9NZM3; O95062; Q15812; Q9HAK4; Q9NXE6; Q9NYG0; Q9NZM2; Q9ULG4
Background:
Intersectin-2, known alternatively as SH3 domain-containing protein 1B, SH3P18, or SH3P18-like WASP-associated protein, plays a pivotal role in cellular processes. It acts as an adapter protein linking endocytic membrane traffic with the actin assembly machinery. This protein is crucial for the maturation of clathrin-coated vesicles, influencing their invagination or budding, and is involved in the endocytosis of key molecules like integrin beta-1 and transferrin receptor. Additionally, it contributes to dendrite formation by melanocytes.
Therapeutic significance:
Understanding the role of Intersectin-2 could open doors to potential therapeutic strategies.