Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9NZT1
UPID:
CALL5_HUMAN
Alternative names:
Calmodulin-like skin protein
Alternative UPACC:
Q9NZT1; Q5SQI3; Q8IXU8
Background:
Calmodulin-like protein 5, also known as Calmodulin-like skin protein, plays a crucial role in the human body by binding calcium. This process is essential for the terminal differentiation of keratinocytes, which are pivotal in the formation of the epidermis, the outermost layer of the skin. The protein's ability to interact with calcium ions highlights its significance in cellular processes.
Therapeutic significance:
Understanding the role of Calmodulin-like protein 5 could open doors to potential therapeutic strategies. Its involvement in skin cell differentiation makes it a promising target for research in skin-related disorders and regenerative medicine. The exploration of this protein's functions could lead to breakthroughs in treating skin conditions and enhancing wound healing.