Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9NZU7
UPID:
CABP1_HUMAN
Alternative names:
Calbrain; Caldendrin
Alternative UPACC:
Q9NZU7; O95663; Q8N6H5; Q9NZU8
Background:
Calcium-binding protein 1, known alternatively as Calbrain and Caldendrin, plays a pivotal role in modulating calcium-dependent activity in various cellular processes. It regulates the function of inositol 1,4,5-triphosphate receptors, voltage-dependent P/Q-type calcium channels, and L-type calcium channels, among others. Its ability to influence intracellular calcium signaling and channel inactivation mechanisms underscores its importance in cellular physiology.
Therapeutic significance:
Understanding the role of Calcium-binding protein 1 could open doors to potential therapeutic strategies. Its involvement in critical calcium-dependent processes suggests its potential as a target for modulating cellular functions in diseases where calcium signaling is disrupted.