Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9P015
UPID:
RM15_HUMAN
Alternative names:
39S ribosomal protein L15, mitochondrial
Alternative UPACC:
Q9P015; Q96Q54; Q9H0Y1
Background:
The Large ribosomal subunit protein uL15m, also known as 39S ribosomal protein L15, mitochondrial, plays a crucial role in protein synthesis within mitochondria. Its involvement in the mitochondrial ribosome's structure suggests a significant function in mitochondrial protein translation, essential for cellular energy production and metabolic processes.
Therapeutic significance:
Understanding the role of Large ribosomal subunit protein uL15m could open doors to potential therapeutic strategies. Its fundamental role in mitochondrial function highlights its potential as a target for diseases related to mitochondrial dysfunction.