Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9P086
UPID:
MED11_HUMAN
Alternative names:
Mediator complex subunit 11
Alternative UPACC:
Q9P086; Q6NS89
Background:
Mediator of RNA polymerase II transcription subunit 11, also known as Mediator complex subunit 11, plays a pivotal role in the transcription process. It acts as a component of the Mediator complex, facilitating the regulated transcription of nearly all RNA polymerase II-dependent genes. This protein serves as a crucial bridge, conveying information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, and is essential for the assembly of a functional preinitiation complex.
Therapeutic significance:
Understanding the role of Mediator of RNA polymerase II transcription subunit 11 could open doors to potential therapeutic strategies.