Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9P0M2
UPID:
AKA7G_HUMAN
Alternative names:
A-kinase anchor protein 18 kDa; Protein kinase A-anchoring protein 7 isoform gamma
Alternative UPACC:
Q9P0M2; B4DUC3; Q9HCZ8
Background:
A-kinase anchor protein 7 isoform gamma, also known as A-kinase anchor protein 18 kDa or Protein kinase A-anchoring protein 7 isoform gamma, plays a crucial role in targeting cAMP-dependent protein kinase (PKA) to cellular membranes or cytoskeletal structures. This protein's interaction with the cellular membrane reduces epithelial sodium channel (ENaC) activity, while its cytoplasmic form may regulate ENaC channel feedback inhibition by intracellular sodium.
Therapeutic significance:
Understanding the role of A-kinase anchor protein 7 isoform gamma could open doors to potential therapeutic strategies, particularly in diseases where ENaC activity is implicated.