Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9P0M9
UPID:
RM27_HUMAN
Alternative names:
39S ribosomal protein L27, mitochondrial
Alternative UPACC:
Q9P0M9; B2RE14
Background:
The Large ribosomal subunit protein bL27m, also known as 39S ribosomal protein L27, mitochondrial, plays a crucial role in the synthesis of proteins within the mitochondria. Its involvement in the mitochondrial ribosome suggests a fundamental contribution to mitochondrial protein synthesis, essential for cellular energy production and metabolic processes.
Therapeutic significance:
Understanding the role of Large ribosomal subunit protein bL27m could open doors to potential therapeutic strategies. Its pivotal function in mitochondrial protein synthesis positions it as a key target for interventions aimed at mitochondrial diseases and disorders related to energy metabolism.