Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9P0U4
UPID:
CXXC1_HUMAN
Alternative names:
CpG-binding protein; PHD finger and CXXC domain-containing protein 1
Alternative UPACC:
Q9P0U4; B2RC03; Q8N2W4; Q96BC8; Q9P2V7
Background:
CXXC-type zinc finger protein 1, also known as CpG-binding protein or PHD finger and CXXC domain-containing protein 1, plays a pivotal role in gene expression. It uniquely binds to CpG unmethylated motifs, with a preference for CpGG, acting as a transcriptional activator. This specificity in DNA binding highlights its potential regulatory functions in genomic regions rich in CpG sites.
Therapeutic significance:
Understanding the role of CXXC-type zinc finger protein 1 could open doors to potential therapeutic strategies. Its unique DNA-binding capability suggests a significant function in regulating gene expression, which could be leveraged in designing interventions for diseases where gene regulation is disrupted.