Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9P0Z9
UPID:
SOX_HUMAN
Alternative names:
L-pipecolate oxidase; L-pipecolic acid oxidase
Alternative UPACC:
Q9P0Z9; B3KNH0; Q96H28; Q9C070
Background:
Peroxisomal sarcosine oxidase, also known as L-pipecolate oxidase or L-pipecolic acid oxidase, plays a crucial role in the metabolism of sarcosine and L-pipecolic acid. This enzyme's activity is pivotal in the catabolic pathways of these substrates, indicating its essential function in cellular metabolism.
Therapeutic significance:
Understanding the role of Peroxisomal sarcosine oxidase could open doors to potential therapeutic strategies. Its involvement in key metabolic processes highlights its potential as a target for therapeutic intervention in metabolic disorders.