Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9P1W9
UPID:
PIM2_HUMAN
Alternative names:
Pim-2h
Alternative UPACC:
Q9P1W9; A8K4G6; Q99739
Background:
Serine/threonine-protein kinase pim-2, also known as Pim-2h, plays a pivotal role in cell survival and proliferation. It exerts oncogenic activity by regulating MYC transcriptional activity, cell cycle progression, cap-dependent protein translation, and survival signaling through phosphorylation of BAD. Additionally, Pim-2 promotes cell survival in response to proliferative signals and growth factor-independent proliferation.
Therapeutic significance:
Understanding the role of Serine/threonine-protein kinase pim-2 could open doors to potential therapeutic strategies. Its involvement in key cellular processes such as cell cycle progression and survival signaling positions it as a critical target for cancer research and drug discovery.