Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9P246
UPID:
STIM2_HUMAN
Alternative names:
-
Alternative UPACC:
Q9P246; A6H8L7; B7ZVY0; Q96BF1; Q9BQH2; Q9H8R1
Background:
Stromal interaction molecule 2 (STIM2) is pivotal in calcium homeostasis, mediating store-operated Ca(2+) entry (SOCE) and regulating cytosolic and endoplasmic reticulum Ca(2+) concentrations. It acts as a sensitive Ca(2+) sensor, activating Ca(2+)-influx mechanisms and potentially inhibiting STIM1-mediated Ca(2+) influx.
Therapeutic significance:
Understanding the role of Stromal interaction molecule 2 could open doors to potential therapeutic strategies.