Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9P2X0
UPID:
DPM3_HUMAN
Alternative names:
Dolichol-phosphate mannose synthase subunit 3; Dolichyl-phosphate beta-D-mannosyltransferase subunit 3; Mannose-P-dolichol synthase subunit 3; Prostin-1
Alternative UPACC:
Q9P2X0; Q5SR62; Q5SR63; Q9BXN4; Q9BXN5
Background:
Dolichol-phosphate mannosyltransferase subunit 3, also known as Dolichol-phosphate mannose synthase subunit 3, plays a crucial role as a stabilizer in the dolichol-phosphate mannose (DPM) synthase complex. This protein is pivotal in tethering the catalytic subunit DPM1 to the endoplasmic reticulum, a key step in glycosylation processes.
Therapeutic significance:
The protein is linked to Muscular dystrophy-dystroglycanopathy congenital with impaired intellectual development B15 and Muscular dystrophy-dystroglycanopathy limb-girdle C15, diseases characterized by muscle weakness and developmental challenges. Understanding its role could lead to novel therapeutic strategies targeting these muscular dystrophies.