Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9UBD5
UPID:
ORC3_HUMAN
Alternative names:
Origin recognition complex subunit Latheo
Alternative UPACC:
Q9UBD5; A2A2T5; B4E025; Q13565; Q53GY6; Q5T159; Q6IUY7; Q86TN5; Q9UG44; Q9UNT6
Background:
The Origin recognition complex subunit 3, also known as Latheo, plays a pivotal role in DNA replication initiation. It is a crucial component of the origin recognition complex (ORC) that binds to origins of replication in an ATP-dependent manner. Despite the lack of identified specific DNA sequences for replication origins, ORC's function in assembling the pre-replication complex is indispensable for DNA replication commencement. Additionally, this protein has an affinity for histone H3 and H4 trimethylation marks, including H3K9me3, H3K27me3, and H4K20me3.
Therapeutic significance:
Understanding the role of Origin recognition complex subunit 3 could open doors to potential therapeutic strategies.