Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9UBD6
UPID:
RHCG_HUMAN
Alternative names:
Rh glycoprotein kidney; Rhesus blood group family type C glycoprotein; Tumor-related protein DRC2
Alternative UPACC:
Q9UBD6; A8K4D4; Q6X3Y4
Background:
The Ammonium transporter Rh type C, also known as Rh glycoprotein kidney, Rhesus blood group family type C glycoprotein, and Tumor-related protein DRC2, plays a crucial role in acid-base homeostasis. It facilitates the transport of ammonium and methylammonium across epithelial cell membranes, contributing to renal ammonia transport and metabolism. This protein operates through an electroneutral bidirectional transport mechanism, crucial for maintaining the body's pH balance.
Therapeutic significance:
Understanding the role of Ammonium transporter Rh type C could open doors to potential therapeutic strategies.