Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9UBP9
UPID:
GULP1_HUMAN
Alternative names:
Cell death protein 6 homolog; PTB domain adapter protein CED-6; Protein GULP
Alternative UPACC:
Q9UBP9; B2RB51; B4DQ40; B8ZZ72; D3DPH1; E9PB86; Q53PC1; Q53RF3; Q9BVL3
Background:
PTB domain-containing engulfment adapter protein 1, also known as Cell death protein 6 homolog, PTB domain adapter protein CED-6, and Protein GULP, plays a crucial role in cellular processes. It functions as an adapter protein, essential for the efficient phagocytosis of apoptotic cells, and modulates cellular glycosphingolipid and cholesterol transport. This protein is involved in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP, and is known to increase cellular levels of GTP-bound ARF6.
Therapeutic significance:
Understanding the role of PTB domain-containing engulfment adapter protein 1 could open doors to potential therapeutic strategies.