Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9UBQ5
UPID:
EIF3K_HUMAN
Alternative names:
Eukaryotic translation initiation factor 3 subunit 12; Muscle-specific gene M9 protein; PLAC-24; eIF-3 p25; eIF-3 p28
Alternative UPACC:
Q9UBQ5; A8K0I9; B7ZAM9; Q96IQ0; Q9Y6D1
Background:
Eukaryotic translation initiation factor 3 subunit K (eIF-3 subunit K) plays a pivotal role in the initiation of protein synthesis. As a component of the eIF-3 complex, it is essential for the recruitment of several key factors to the 43S pre-initiation complex, facilitating mRNA recruitment and scanning. Its involvement in cell proliferation, differentiation, and apoptosis highlights its importance in cellular functioning.
Therapeutic significance:
Understanding the role of Eukaryotic translation initiation factor 3 subunit K could open doors to potential therapeutic strategies.