Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9UEY8
UPID:
ADDG_HUMAN
Alternative names:
Adducin-like protein 70
Alternative UPACC:
Q9UEY8; D3DRA8; O43243; Q5VU09; Q92773; Q9UEY7
Background:
Gamma-adducin, also known as Adducin-like protein 70, is a membrane-cytoskeleton-associated protein pivotal in promoting the assembly of the spectrin-actin network. It plays a crucial role in actin filament capping and binds to calmodulin. This protein is involved in the regulation of vascular smooth muscle cells, affecting renal and cerebral blood flow, and plays a significant role in podocyte structure and function.
Therapeutic significance:
Gamma-adducin's involvement in cerebral palsy, spastic quadriplegic 3, a neurodevelopmental disorder characterized by spasticity and cognitive impairment, underscores its therapeutic potential. Understanding the role of Gamma-adducin could open doors to potential therapeutic strategies for this condition.