Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9UGI0
UPID:
ZRAN1_HUMAN
Alternative names:
TRAF-binding domain-containing protein; Zinc finger Ran-binding domain-containing protein 1
Alternative UPACC:
Q9UGI0; B4DZ98; D3DRF4; Q5SQP6; Q69YK3
Background:
Ubiquitin thioesterase ZRANB1, also known as TRAF-binding domain-containing protein or Zinc finger Ran-binding domain-containing protein 1, plays a pivotal role in cellular processes. It specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin, with a lesser efficiency for 'Lys-63'-linked chains. ZRANB1 is a positive regulator of the Wnt signaling pathway through deubiquitination of APC protein. It also mediates deubiquitination of PIK3C3/VPS34, promoting autophagosome maturation, and is involved in cell morphology and cytoskeletal organization.
Therapeutic significance:
Understanding the role of Ubiquitin thioesterase ZRANB1 could open doors to potential therapeutic strategies.