Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9UGM3
UPID:
DMBT1_HUMAN
Alternative names:
Glycoprotein 340; Hensin; Salivary agglutinin; Surfactant pulmonary-associated D-binding protein
Alternative UPACC:
Q9UGM3; A6NDG4; A6NDJ5; A8E4R5; B1ARE7; B1ARE8; B1ARE9; B1ARF0; B7Z8Y2; F8WEF7; Q59EX0; Q5JR26; Q6MZN4; Q96DU4; Q9UGM2; Q9UJ57; Q9UKJ4; Q9Y211; Q9Y4V9
Background:
Deleted in malignant brain tumors 1 protein, also known as Glycoprotein 340, Hensin, Salivary agglutinin, and Surfactant pulmonary-associated D-binding protein, plays a pivotal role in mucosal defense, cellular immune defense, and epithelial differentiation. It is involved in various biological processes including liver regeneration, taste sensation regulation, and acts as a binding protein for broad bacterial specificity.
Therapeutic significance:
Given its involvement in gliomas and its potential role as a tumor suppressor in brain, lung, esophageal, gastric, and colorectal cancers, understanding the role of Deleted in malignant brain tumors 1 protein could open doors to potential therapeutic strategies.