Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9UH03
UPID:
SEPT3_HUMAN
Alternative names:
-
Alternative UPACC:
Q9UH03; B1AHR0; Q2NKJ7; Q59GF7; Q6IBZ6; Q8N3P3; Q9HD35
Background:
Neuronal-specific septin-3, a filament-forming cytoskeletal GTPase, is implicated in crucial cellular processes. By similarity, it is known to contribute to the architecture of the cytoskeleton. Its potential role in cytokinesis highlights its importance in cell division, suggesting a fundamental function in maintaining cellular integrity and dynamics.
Therapeutic significance:
Understanding the role of Neuronal-specific septin-3 could open doors to potential therapeutic strategies. Its involvement in key cellular processes underscores its potential as a target for therapeutic intervention, particularly in diseases where cell division and cytoskeletal dynamics are disrupted.