Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9UHA4
UPID:
LTOR3_HUMAN
Alternative names:
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; MEK-binding partner 1; Mitogen-activated protein kinase kinase 1-interacting protein 1; Mitogen-activated protein kinase scaffold protein 1
Alternative UPACC:
Q9UHA4; B2R4A1; J3KMX4; Q9H364
Background:
Ragulator complex protein LAMTOR3, also known as Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3, plays a pivotal role in amino acid sensing and activation of mTORC1. This process is crucial for cell growth in response to various stimuli including growth factors, energy levels, and amino acids. LAMTOR3, as part of the Ragulator complex, activates Rag GTPases and recruits mTORC1 to lysosomes, facilitating its activation.
Therapeutic significance:
Understanding the role of Ragulator complex protein LAMTOR3 could open doors to potential therapeutic strategies.