Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9UHD1
UPID:
CHRD1_HUMAN
Alternative names:
CHORD domain-containing protein 1; Protein morgana
Alternative UPACC:
Q9UHD1; B2R6P8; Q6IN49; Q8WVL9; Q9H3D6
Background:
Cysteine and histidine-rich domain-containing protein 1, also known as CHORD domain-containing protein 1 or Protein morgana, plays a pivotal role in cellular processes. It regulates centrosome duplication, acts as a co-chaperone for HSP90, and is involved in the regulation of NOD1 via a HSP90 chaperone complex. Its intrinsic chaperone activity, stress response functions, and role in preventing tumorigenesis highlight its significance in cellular integrity and function.
Therapeutic significance:
Understanding the role of Cysteine and histidine-rich domain-containing protein 1 could open doors to potential therapeutic strategies.