Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9UHP9
UPID:
SMPX_HUMAN
Alternative names:
Stretch-responsive skeletal muscle protein
Alternative UPACC:
Q9UHP9; B1AWX2
Background:
The Small muscular protein, also known as Stretch-responsive skeletal muscle protein, plays a pivotal role in the regulatory network that enables muscle cells to coordinate their structural and functional states during growth, adaptation, and repair. This protein's unique function underscores its importance in muscle physiology.
Therapeutic significance:
Linked to diseases such as Deafness, X-linked, 4, and Myopathy, distal, 7, adult-onset, X-linked, the Small muscular protein's involvement in these conditions highlights its potential as a target for therapeutic intervention. Understanding the role of Small muscular protein could open doors to potential therapeutic strategies.