Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9UI42
UPID:
CBPA4_HUMAN
Alternative names:
Carboxypeptidase A3
Alternative UPACC:
Q9UI42; B7Z576; Q86UY9
Background:
Carboxypeptidase A4, also known as Carboxypeptidase A3, is a metalloprotease implicated in the histone hyperacetylation pathway. It selectively cleaves C-terminal amino acids, showing preference for Phe, Leu, Ile, Met, Tyr, and Val. This specificity suggests a critical role in protein processing and regulation.
Therapeutic significance:
Understanding the role of Carboxypeptidase A4 could open doors to potential therapeutic strategies. Its involvement in protein processing and histone modification pathways positions it as a key target for drug discovery, aiming to modulate its activity for therapeutic benefits.