Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9UJT1
UPID:
TBD_HUMAN
Alternative names:
Delta-tubulin
Alternative UPACC:
Q9UJT1; B4DPT8; B4DW01; D3DU02; E9PCA7; E9PCQ8; Q5KU36; Q9BWG9; Q9H7Z8
Background:
Tubulin delta chain, also known as Delta-tubulin, plays a crucial role in hedgehog signaling and ciliary function. This protein is essential for the proper functioning of cilia, microscopic hair-like structures that protrude from the surface of many cell types. Cilia are involved in various processes, including cell movement, sensing the cellular environment, and signaling pathways.
Therapeutic significance:
Understanding the role of Tubulin delta chain could open doors to potential therapeutic strategies. Its involvement in hedgehog signaling, a pathway critical in developmental processes and implicated in various diseases, highlights its potential as a target for drug discovery. By modulating the activity of this protein, it may be possible to develop treatments for conditions related to aberrant hedgehog signaling.