Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9UK73
UPID:
FEM1B_HUMAN
Alternative names:
FEM1-beta; Fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha
Alternative UPACC:
Q9UK73; O43146
Background:
Protein fem-1 homolog B, known as FEM1-beta, plays a crucial role in the ubiquitination and degradation of proteins via the DesCEND pathway. It specifically targets proteins with a C-degron motif at their C-terminus, including CDK5R1, leading to their degradation. This protein is also pivotal in regulating the reductive stress response, apoptosis, and glucose homeostasis in pancreatic islet.
Therapeutic significance:
Understanding the role of Protein fem-1 homolog B could open doors to potential therapeutic strategies.