Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9UKD1
UPID:
GMEB2_HUMAN
Alternative names:
DNA-binding protein p79PIF; Parvovirus initiation factor p79
Alternative UPACC:
Q9UKD1; E1P5J3; Q5TDS0; Q9H431; Q9H4X7; Q9H4X8; Q9UF78; Q9ULF1
Background:
Glucocorticoid modulatory element-binding protein 2, also known as DNA-binding protein p79PIF and Parvovirus initiation factor p79, plays a pivotal role in cellular processes. It binds to glucocorticoid modulatory elements in the TAT promoter, enhancing sensitivity to glucocorticoids, and interacts with the transferrin receptor promoter. This protein is also an essential auxiliary factor for parvovirus replication.
Therapeutic significance:
Understanding the role of Glucocorticoid modulatory element-binding protein 2 could open doors to potential therapeutic strategies.