Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9UL16
UPID:
CFA45_HUMAN
Alternative names:
Coiled-coil domain-containing protein 19; Nasopharyngeal epithelium-specific protein 1
Alternative UPACC:
Q9UL16; C9JH28; Q05BA3; Q5VU18
Background:
Cilia- and flagella-associated protein 45, also known as Coiled-coil domain-containing protein 19 and Nasopharyngeal epithelium-specific protein 1, plays a crucial role in the structure and function of motile cilia. It is a Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules in cilia axoneme, essential for motile cilia beating. This protein is an AMP-binding protein that facilitates dynein ATPase-dependent ciliary and flagellar beating via adenine nucleotide homeostasis.
Therapeutic significance:
The protein's involvement in Heterotaxy, visceral, 11, autosomal, with male infertility, highlights its potential in therapeutic strategies targeting congenital defects and male infertility. Understanding the role of Cilia- and flagella-associated protein 45 could open doors to potential therapeutic strategies.