Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9UL33
UPID:
TPC2L_HUMAN
Alternative names:
-
Alternative UPACC:
Q9UL33; B2R4M9; Q6ZTA7; Q9NZZ4
Background:
Trafficking protein particle complex subunit 2-like protein plays a crucial role in vesicular transport from the endoplasmic reticulum to the Golgi apparatus. This process is fundamental for the proper functioning and distribution of proteins within the cell.
Therapeutic significance:
The protein is linked to Encephalopathy, progressive, early-onset, with episodic rhabdomyolysis, a severe disease marked by neurodevelopmental delay and epilepsy. Understanding its role could lead to novel therapeutic strategies for this debilitating condition.